Citation: Ying SONG, Li Jian LIU, Ren Xi ZHUO. Microwave-assisted Polymerization of ε-Caprolactone with Maleic Acid as Initiator and Drug Release Behavior of Ibuprofen-Poly(ε-caprolaetone) System[J]. Chinese Chemical Letters, ;2003, 14(1): 32-34. shu

Microwave-assisted Polymerization of ε-Caprolactone with Maleic Acid as Initiator and Drug Release Behavior of Ibuprofen-Poly(ε-caprolaetone) System

Department of Polymer Science, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072

Received Date: 1 April 2002

Fund Project: This work was financially supporlcd by The Research Foundalion of MOE and National 973 Projccl ofChina (G1999064703).

Poly(ε-caprolactone) (PCL) with weight-average molar mass over 10000 g/mol was synthesized by microwave-assisted ring-opening polymerization of ε-caprolactonc (ε-CL) with malcic acid (MA) as initiator (2.45 GHz, 360 W, 85 min). Ibuprofen-PCL controlled release system was prepared directly by the ROP of ε-CL in its mixture with ibuprofen. The release of ibuprofen from the system was sustained and steady.
- Microwave,
- ring-opening polymerization,
- poly (ε-caprolactone),
- maleic acid,ibuprofen,
- drug release
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