Citation: Shao Ning WANG, Ying Kun QIU, Hui XU, Yi Hui DENG, Da Wei CHEN. Synthesis and Characterization of a Novel Galactosylated Cholesterol[J]. Chinese Chemical Letters, ;2006, 17(2): 173-176. shu

Synthesis and Characterization of a Novel Galactosylated Cholesterol

1.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016;
2.
School of Pharmcy, Yantai University, Yantai 264005;
3.
Shandong Engineering Research Center of Natural Drugs, Yantai 264003

Received Date: 2 June 2005

A novel galactosylated cholesterol with mono-galactoside moiety, (5-cholesten-3-yl)4-oxo-4-[2-(lactobionylamido)ethylamido]butanoate 6 was synthesized. Its chemical structure was characterized by IR, ESI-MS, ¹³C NMR, ¹H NMR. Doxorubicin entrapped in the liposomes containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymal cells in mice.
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