Citation: Fei DENG, Fu Jun ZHANG, Ming ZHAO, Yi Ping WANG, Jin Sheng ZHANG. Synthesis and Antioxidant Activity of Sapriparaquinone Analogues[J]. Chinese Chemical Letters, ;2006, 17(9): 1177-1180. shu

Synthesis and Antioxidant Activity of Sapriparaquinone Analogues

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203

Received Date: 20 March 2006

Fund Project: The authors are grateful to the Chinese Academy of Sciences and the National Natural Science Foundation of China (No. 39830040) for their financial support. All of the spectrum data were performed by the analytical center of our institute.

Twenty two sapriparaquinone derivatives were synthesized and their antioxidant activities were evaluated in vitro. Many of this kind of compounds demonstrated potent antioxidant activity against lipid peroxidation, especially compound 7 (IC₅₀=3.7 μg/mL). The preliminary structure-activity relationship of sapriparaquinone derivatives was discussed.
- Synthesis,
- sapriparaquinone,
- antioxidant activity
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