Citation: Wei Shuo FANG, Qi Cheng FANG, Xiao Tian LIANG. Synthesis of 14-Bromo and 14-Hydroxy Baccatin Ⅲ Derviatives[J]. Chinese Chemical Letters, ;2001, 12(8): 675-678. shu

Synthesis of 14-Bromo and 14-Hydroxy Baccatin Ⅲ Derviatives

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050

Received Date: 2 January 2001

Fund Project: This work is partly sponsored by funding to Outstanding Doctor Thesis Authors of Chinese Universities (grant No. 199949) from Ministry of Education of P. R. China which was gratefully acknowledged by W. S. Fang.

Several 14α-and 14β-bromo baccatin Ⅲ derivatives were synthesized by direct bromination and from silyl enol ether of 13-oxo-7-TES-baccatin Ⅲ. 14β-Hyroxy baccatin Ⅲ derivative was also obtained from the same silyl enol ether.
- 14-Bromo baccatin Ⅲ,
- 14-hydroxy baccatin Ⅲ,
- paclitaxel,
- silyl enol ether.
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