Citation: Hui Hui ZENG, Jeong Yun CHOI, Myung Hee CHUNG. 8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways[J]. Chinese Chemical Letters, ;2003, 14(5): 529-532. shu

8-Hydroxyguanine, A Product From Damaged DNA Can Be Used in the DNA Salvage Pathways

1.
School of Pharmaceutical Sciences, Peking University, Beijing 100083;
2.
Department of Pharmacology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea

Received Date: 2 July 2002

The metabolic mechanism of 8-hydroxyguanine (8-OHGua) is so far unknown, however it is known to function in the mutagenic events in biological systems.In the present study, the metabolic processes is investigated by the reaction of 8-OHGua with PRPP catalyzed by HGPRT and Mg(Ⅱ).The evidence shows that the interaction between 8-OHGua and the enzyme is indeed taken place and 8-OHGMP is formed.
- 8-Hydroxyguanine,
- metabolic reaction,
- DNA salvage pathway
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