Citation: Wen PEI, Kobe JOZE. Preparation of Platinum (Ⅱ) Complexes with 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and its Deoxy-analogue[J]. Chinese Chemical Letters, ;2001, 12(6): 559-562. shu

Preparation of Platinum (Ⅱ) Complexes with 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide and its Deoxy-analogue

Wen PEI ¹ ,
Kobe JOZE ²

1.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
2.
National Institute of Chemistry, Hajdrihova 19, SI-1115 Ljubljana, Slovenia

Received Date: 26 May 2000

The platinum (Ⅱ) complexes of the [Pt (N⁴,N⁷-Ribavirin) (DMSO) Cl],[Pt (N⁴,N⁷-De-oxyribavirin) (DMSO) Cl] were obtained by the reactions of cis-[Pt (DMSO)₂ Cl₂] and K[Pt (DMSO) Cl₃] with 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin) and its deoxy-analogue (deoxyribavirin). The preparation of 1-(2'-deoxy-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide was also performed through a four-step procedure, protection of 3', 5'-dihydroxyl group of Ribavirin with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TPDS-Cl), phenoxythio-carbonylation of the 2'-hydroxyl group of 3', 5'-O-TPDS-Ribavirin with phenoxythiocarbonyl-chloride (PTC-Cl), reduction of 2'-O-phenoxythiocarbonyl ester of 3', 5'-O-TPDS-Ribavirin with tri-n-butyltin hydride and AIBN, deprotection of 3', 5'-O-TPDS-Ribavirin with tetrabutylammon-ium fluoride in THF.
- Platinum(Ⅱ) complexes,
- ribavirin and deoxyribavirin,
- nucleobase platination,
- complexation reaction,
- antitumor agents.
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