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Citation: Hong Bing LIU, Cheng Bin CUI, Bing CAI, Qian Qun GU, Dong Yun ZHANG, Qing Chun ZHAO, Hua Shi GUAN. Pterocarine, a New Diarylheptanoid from Pterocarya tonkinesis, its Cell Cycle Inhibition at G₀/G₁Phase and Induction of Apoptosis in HCT-15 and K562 Cells[J]. Chinese Chemical Letters, ;2005, 16(2): 215-218. shu

Pterocarine, a New Diarylheptanoid from Pterocarya tonkinesis, its Cell Cycle Inhibition at G₀/G₁Phase and Induction of Apoptosis in HCT-15 and K562 Cells

1.
Key Laboratory of Marine Drugs, Ministry of Education, China;Marine Drug and Food Institute, Ocean University of China, Qingdao 266003;
2.
Tianjin Institute for Biomedicinal Research (TIBiR), Tanjin 300384;
3.
Beijing Institute of Pharmacology and Toxicology, AMMS, Beijing 100850

Received Date: 5 January 2004

Fund Project: Dr. H. Osada, head of the Antibiotics Laboratory, the Institute of Physical and Chemical Research (RIKEN), Japan, kindly provided the tsFT210 cell line. This work was supported by the Fund from the National Natural Science Foundation of China (C.-B. CUI, No. 39825126), the Fund for the 973-project from Ministry of Science and Technology (C.-B. CUI, No. 1998051113), China, and the Fund for Cheung Kong Scholar (C.-B. CUI) from Cheung Kong Scholars Program, Ministry of Education of China. The plant materials were collected and identified by Prof. Q.S. Sun of Shenyang Pharmaceutical University, China.

Pterocarine (1), a new diarylheptanoidal compound, was isolated from Pterocarya tonkinesis (Franch.) Dode. together with a known diarylheptanoid, myricatomentogenin (2), through a bioassay-guided fractionation procedure. The structure of 1 was elucidated as (+)-3', 4"-epoxy-1-(4'-hydroxyphenyl)-7-(3"-hydroxyphenyl)-heptane-3-one by the spectroscopic methods.Pterocarine (1) inhibited the proliferation of tsFT210, HCT-15 and K562 cells with the inhibition rates of 20.2±2.4, 23.8±2.4 and 50.5±1.2% at 100μg/mL, respectively. Flow cytometric analysis indicated that 1 could inhibit the cell cycle of tsFT210, HCT-15 and K562 cells at the G₀/G₁ phase and could also induce apoptosis in HCT-15 (19%) and K562 (11%) cells.
- Pterocarine,
- diarylheptanoid,
- phenolic compound,
- structure,
- cell cycle inhibitor,
- apop-tosis inducer,
- Pterocarya tonkinesis,
- Juglandaceae.
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1.
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