Citation: Dong Mei CAI, Min Jie LI, Da Liang LI, Tian Pa YOU. Synthesis of C-Nucleoside Analogues: 2-[2-(Hydroxymethyl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide and 2-[2-(Mercaptometh-yl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide[J]. Chinese Chemical Letters, ;2004, 15(2): 163-166.
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Novel C-nucleosides of tiazofurin analogue (2-[2-(hydroxymethyl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide) and its thiol-substituted derivative (2-[2-(mercaptomethyl)-1, 3-dioxolan-5-yl]1, 3-thiazole-4-carboxamide) were synthesized from methyl acrylate through a multistep procedure. Their structures were confirmed by IR, 1HNMR, 13CNMR and elemental analysis.
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Keywords:
- C-Nucleosides,
- tiazofurin,
- selenazofurin,
- 1, 3-dioxolane,
- thiol-substituted
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