Citation: Lai Jin TIAN, Yu Xi SUN, Guo Ming YANG, Bo Chu QIAN, Zhi Cai SHANG. Formation, Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex[J]. Chinese Chemical Letters, ;2005, 16(12): 1584-1586. shu

Formation, Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex

1.
Department of Chemistry, Qufu Normal University, Qufu 273165;
2.
Department of Chemistry, Zhejiang University, Hangzhou 310027;
3.
Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013

Received Date: 1 April 2005

Fund Project: This work was supported by the Natural Science Foundation of Shandong Province (No.Z2002F01) and Qufu Normal Universiy.

A 1:1 reaction of triphenyltin chloride with potassium N-[(3,5-dibromo-2-hydroxyl-phenyl)methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex,(HL)SnPh₃·Ph₂SnL[L=2-O-3,5-Br₂C₆H₃CH=NCH(i-Pr)COO],by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O₂SnC₂N and a trans-O₂SnC₃ in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antimmor activity of the complex against three human tumour cell lines (HeLa, CoLo205 and MCF-7) was found to be much higher than cis-platin used in clinic.
- Binuclear tin complex,
- organotin carboxylate,
- antitumor activity,
- crystal structure
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