Citation: Qi WU, Jian Yue FENG, Chen Guo FENG, De Shui LU, Xian Fu LIN. Enzymatic regioselective symthesis of vinthesis of vinyl lactose ester and its chemical polymerization[J]. Chinese Chemical Letters, ;2002, 13(5): 416-419. shu

Enzymatic regioselective symthesis of vinthesis of vinyl lactose ester and its chemical polymerization

Department of Chemistry, Zhejiang University, Hangzhou 310027

Received Date: 21 August 2001

Transesterification reaction of lactose with divinyladipate in pyridine catalyzed by an alkaline protease from Bacillus subtilis at 50℃ for 3 days gave 6'-O-vinyladipoyl-lactose (yield 35%). Poly(6'-O-vinyladipoyl-lactose) with Mn=21,200, Mw=32,900, Mw/Mn=1.56 could be obtained by chemical polymerization. Poly(vinyl alcohol) containing lactose branch was biodegradable. After 6 days in aqueous buffer (PH 7), this alkaline protease could degrade the polymer to an Mn of ca. 2100, Mw/Mn=2.56.
- Regioselectivity,
- vinyl ester,
- lactose,
- alkaline protease,
- polymerization
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