Citation: . RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*[J]. Chinese Journal of Polymer Science, ;1999, 17(3): 265-270. shu

RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS*

Received Date: 19 February 1998

Poly-dl -lactide-poly(ethylene glycol ) (PELA) triblock copolymers were synthesized withlanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outermembrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods.The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0μm, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues,such as the liver,spleen and intestinal peyer's patches,following oral administration.The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.
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