Citation: Hong Xia DING, Wei LU, Lei Xiang YANG, Hai Bo LI, Hua BAI, Xiu Mei WU, Jun Chao CAI, Yu ZHAO. Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue[J]. Chinese Chemical Letters, ;2006, 17(1): 5-8. shu

Synthesis of A Natural Cytotoxic Alkaloid Artabotrine and its Analogue

Hong Xia DING ^1, ,
Wei LU ² ,
Lei Xiang YANG ¹ ,
Hai Bo LI ¹ ,
Hua BAI ³ ,
Xiu Mei WU ³ ,
Jun Chao CAI ² ,
Yu ZHAO ¹

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
Shanghai Institute of Material Medica, Chinese Academy of Sciences, SIBS, Shanghai 200031;
3.
Zhejiang Hisun Naturelite Pharmaceutical R&D Co., Ltd., Hangzhou 310007

Received Date: 18 April 2005

Artabotrine 1 is a novel N-methoxylated 4, 5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.
- Artabotrine,
- aporphine alkaloid,
- cytotoxicity,
- synthesis
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