Citation: Zhi Ming LI, Bing WANG, Feng Gang TAO, Guo Qiang LIN. Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C[J]. Chinese Chemical Letters, ;2004, 15(2): 138-140. shu

Studies on the Synthesis of Penazetidine A, an Alkaloid Inhibitor of Protein Kinase C

1.
Department of Chemistry, Fudan University, Shanghai 200433;
2.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received Date: 11 January 2003

A convergent asymmetric synthesis of (2S, 3R, 4S, 12'R)-3-hydroxy-2-hydroxymethyl-4-(12'-methyloctadecyl)-N-(p-tolylsulfonyl)-azetidine, a key precursor of penazetidine A, has been achieved by starting from divinylcarbinol.
- Penazetidine A,
- alkaloid,
- azetidine,
- Wittig reaction
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