Citation: Ji Cheng CHU, Hong Sheng GUO, Jun Biao CHANG, Kang ZHAO. Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil[J]. Chinese Chemical Letters, ;2004, 15(7): 785-786. shu

Synthesis of Novel Nucleoside Analog (3R)-2,3-Dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl Uracil

College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072

Received Date: 1 July 2003

Fund Project: We thank the supports from the National Young Scholar Award of the NNSFC (#30125043) and from the Chung Kong Scholars Program Administered by the Ministry of Education, PRC and the Li Ka Shing Foundation, Hong Kong.

The synthesis of novel nucleoside analog (3R)-2,3-dideoxy-3-(N-hydroxy-N-methylamino)-L-arabinofuranosyl uracil was studied. A twelve-step synthetic route, started from L-ascorbic acid, was designed, and the final product was obtained in 20.8% yield.
- L-Nucleoside,
- Wittig reaction,
- Michael addition,
- uracil analog
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