Citation: He ZHAO, Yu Lin WU. ASYMMERIC SYNTHESIS OF 2-ARYLPROPIONIC ACIDS[J]. Chinese Chemical Letters, ;1994, 5(6): 461-464. shu

ASYMMERIC SYNTHESIS OF 2-ARYLPROPIONIC ACIDS

He ZHAO ,
Yu Lin WU

State key laboratory of Bio-Organic & Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of sciences, Shanghai 200032

Received Date: 31 January 1994

(S)-2-(6-methoxy-2-naphtyl)-propionic acid (S-Naproxen) 1 and (S)-2-(4-isobutylphenyl)-propionic acid (S-Ibuprofen) 2 have been synthesized enantioselectively. The steoreochemistry was established by a combination of Sharpless asymmetric dihydroxylation and catalytic hydrogenolysis of the chiral terminal epoxide.
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