Citation: Jian Lei KANG, Zhi Bing ZHENG, Dan QIN, Li Li WANG, Song LI. Synthesis of 2-(Benzodioxol-2-yl)acetic Acids as PPARδ Agonists[J]. Chinese Chemical Letters, ;2006, 17(8): 1013-1016. shu

Synthesis of 2-(Benzodioxol-2-yl)acetic Acids as PPARδ Agonists

1.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016;
2.
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850

Received Date: 13 February 2006

Fund Project: This work was supported by the National High Technology Research and Development Program of China (863 project: 2003AA235010) and the National Natural Science Foundation of China (No. 30472092).

A new series of compounds, 2-(benzodioxol-2-yl)acetic acids, have been synthesized. Their structures were confirmed by MS and ¹H-NMR. The preliminary pharmacological screening showed that these compounds exhibited potent human PPARδ agonist activities.
- PPARδ agonists,
- 2-(benzodioxol-2-yl)acetic acids,
- synthesis
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