Citation: Zhan Zhu LIU, Shi Zhi CHEN. A Case of Abnormal Bishler-Napieralski Cyclization Reaction, Leading to Form Benzyl Oxazole Derivatives[J]. Chinese Chemical Letters, ;2001, 12(3): 195-196. shu

A Case of Abnormal Bishler-Napieralski Cyclization Reaction, Leading to Form Benzyl Oxazole Derivatives

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 24 August 2000

A benzyl oxazole compound 3 was obtained with an excellent yield of 90% when Nacetyl-(2'-methoxy-4',5'-methylenedioxy)-phenylalanine methyl ester 1 was refluxed in POCl₃/benzene. However, the anticipated product 3,4-dihydroisoquinoline-3-carboxylic acid methyl ester 2 could not be found. The mechanism was discussed in this article.
- N-Acetyl amino acid,
- oxazole,
- Bishler-Napieralski reaction
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