Citation: Zhi Yu LIU, Rui Fang WANG, Yue Hai SHEN. Synthesis of the C_11-16+C₂₇ Segment of Epothilone A[J]. Chinese Chemical Letters, ;1998, 9(1): 35-38. shu

Synthesis of the C_11-16+C₂₇ Segment of Epothilone A

Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, 354 Fenglin Lu. Shanghai 200032

Received Date: 23 October 1997

A chiral synthesis of the C_11-16+C₂₇ segment of epothilone A is described using inex-pensive L-(-)-malic acid as starting materinal and using Sharpless asymmetric epoxidation for in-troduction of the desired 12,13 epoxide.
- Epothilone A,
- L-(-)-malic acid,
- asymmetric epoxidation
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