Citation: Ya wei LI, Jun LI, Shao Tang ZHU, Tong Hui ZHOU. GC-MS STUDY ON DIURETICS IN URINE Ⅰ.BETECTION METHOD USING METHYLATION[J]. Chinese Chemical Letters, ;1990, 1(3): 225-228. shu

GC-MS STUDY ON DIURETICS IN URINE Ⅰ.BETECTION METHOD USING METHYLATION

Institute of Materia Medica Chinese Academy of Medical Sciences Beijing 100050 China

Received Date: 9 January 1990

Fund Project: The authors wish to express their gratitude to Dr. R. Masse, Univ. du Quebec, Canada, for his kindly supply of authentic standards of diuretics.

A reliable and sensitive method is developed for the detection of common diuretics in human urine. diuretics along with probenecid are methylated and subjected to GC-MS analysis.Both chromatographic and mass spectrometric data are obtained in selected ion monitoring and full scanning modes.The average detection limit is 0.1-1.0 ug/mi urine.This method is suitable to large-scale and routine screening or confirmation of diuretics in doping control.
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