Citation: Xue Sheng MO, Yao Zeng HUANG. Stereospecific　synthesis　of　(E)-β-Trifluoroacetylvinyl　Handes　and　Their　Palladium-Catalyzed　Coupling　Reachon　with　Organozinc　Reagents[J]. Chinese Chemical Letters, ;1996, 7(4): 301-302. shu

Stereospecific　synthesis　of　(E)-β-Trifluoroacetylvinyl　Handes　and　Their　Palladium-Catalyzed　Coupling　Reachon　with　Organozinc　Reagents

Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry;Chinese Academy of Sciences. 354 Fenglin Lu, Shanghai 200032

Received Date: 10 October 1995

Fund Project: We warmly thank Professor Li-xin Dai for his valuable suggestions. Support of this research by the National Natural Science Foundation of China and Chinese Academy of Sciences is gratefully acknowledged.

The halogenation of (Z)-β-Trifluoroacetylvinyltelluride 1 leads to the unexpected pure (E)-β-trifluoroacetylvinyl halides 3,which are allowed to react with organozinc reagents 4 catalyzed by Pd (0) to furnish the corresponding (E)-α,β-unsaturated trifluoromethyl ketones 5 in good yields.
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