Citation: Xue Mei WANG, Lin Tao CAI. Spectroscopic Study of the Interaction between New Fluorescent Dyes with Nucleic Acids[J]. Chinese Chemical Letters, ;1999, 10(12): 1045-1048. shu

Spectroscopic Study of the Interaction between New Fluorescent Dyes with Nucleic Acids

National 1ab of molecular and biomolecular electronics Southeast University Naming 210096

Received Date: 15 June 1999

A series of new dansylamide derivatives have been synthesized and the specific binding affinity of such fluorophores to nucleic acids has been investigated by using absorption, circular dichroism (CD), fluorescence and atomic force microscopy (AFM) The results indicate that the positive charge of the ligand and the π-π stacking between the dansyl part of the ligand and the DNA base pair may play an important role when binding to polynucleotides.
- Spectroscopic study,
- fluorophors,
- complexation,
- nucleic acids
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