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Citation: Ji Yafei, Zhang Yanqiu, Shi Junying. Improvement in Vitamin K₁ Synthesis[J]. Chinese Journal of Applied Chemistry, ;1998, 15(4): 98-100. shu

Improvement in Vitamin K₁ Synthesis

1.
Department of Energy Utilization and Chemical Engineering, China University of Mining and Technology, Xuzhou 221008;
2.
Research Institute of Fine Chemicals, East China University of Science and Technology, Shanghai

Received Date: 9 October 1997
Revised Date: 25 December 1997

The Ruettimnann's method^[5] for vitamin K₁ synthesis has been improved by using phase transfer catalyst in Diels-Alder condensation and using mixed trans-cis phytyl chloride instead of natural phytol as starting material in the synthesis. The vitamin K₁ then obtained by a retro-Diels-Alder reaction has a cis-trans isomer ratio of 20.35 to 79.65 which meets the Chinese pharmacopia standard. Phytyl bromide in this case gave vitamin K₁ with cis-trans ratio of 26.30 to 73.70.
- vitamin K₁,
- synthesis,
- phytyl chloride,
- phytyl bromide
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Improvement in Vitamin K₁ Synthesis