Citation: Jian Lin PAN, Yan Guang WANG, Jian Feng SHI, Yao Zu CHEN. Synthesis of New Spin Labeled Derivatives of Podophyllotoxin as Potential Anticancer Agents[J]. Chinese Chemical Letters, ;1997, 8(3): 207-208. shu

Synthesis of New Spin Labeled Derivatives of Podophyllotoxin as Potential Anticancer Agents

Department of Chemistry, Zhejiang University, Hangzhou 310027

Received Date: 21 October 1996

Fund Project: This work was financially supported by the National Natural Science Foundation of China and the Natural Science Foundation of Zhejiang Province.

Five new nitroxyl spin labeled podophyllotoxins (2-6) have been synthesized. Compounds 2 and 3 have been tested for their anticancer activity in vitro.The results showed that compound 3 is much more potent than the clinically used etoposide (VP-16) in its inhibition of P388 cells,while compound 2 is not active.
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