Citation: Yu FANG, Dao Dao HU, Zi Li ZHAO, Yun Chao MA, Zuo Min SUN. EFFECTS OF BAICALEIN, WOGONIN, BAICALIN AND Na₂MoO₄ ON N-NITROSATION REACTION[J]. Chinese Chemical Letters, ;1991, 2(10): 823-826. shu

EFFECTS OF BAICALEIN, WOGONIN, BAICALIN AND Na₂MoO₄ ON N-NITROSATION REACTION

a. Department of Chemistry, Shanxi Normal University, Xi'an, 710062;
b. Beijing College of Traditional Chinese Medicine, Beijing, 100029

Received Date: 7 August 1991

The in vitro effects of baicalein,wogonin,baicalin and Na₂MoO₄ on N-nitrosation reaction have been studied. The N-nitrosation reaction has been determined by the amount of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) produced using the UV-photclysis spectrophotometric and pyrolysis gas chromatography test. Baicalein,wogonin and Na₂MoO₄ showed varing extents of inhibition of the formation of DMN and DEN. Baicalin promoted the formation of DMN and DEN under the condition of simulating gastric Juices. It is also found that E. coli showed a remarkable promoting effect on the formation of DMN and DEN,but this promoting effect could be blocked to some extent by baicalein,wogonin,baicalin and Na₂MoO₄. Besides, Na₂MoO₄ and wogonin have shown synergic effect on the blocking of N-nitrosation reaction.
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