Citation: Da Zhi LI, Xin Ya HE, Hui WANG, Li SUN, Bing Cheng LIN. Study of Interaction between Red-tide Toxin,Domoic Acid and Double-stranded DNA by Capillary Zone Electrophoresis[J]. Chinese Chemical Letters, ;2004, 15(9): 1079-1082. shu

Study of Interaction between Red-tide Toxin,Domoic Acid and Double-stranded DNA by Capillary Zone Electrophoresis

Da Zhi LI ^1, ,
Xin Ya HE ¹ ,
Hui WANG ¹ ,
Li SUN ² ,
Bing Cheng LIN ¹

1.
Dalian Institute of Chemical Physics, Chinese academy of Sciences, Dalian 116023;
2.
Dalian Customs Laboratory, Dalian 116001

Received Date: 18 August 2003

Fund Project: The authors gratefully acknowledge the support of the NNSFC (grant No.20035010) and Alexander von Humboldt Foundation (AvH).

The interactions between amnesic red-tide toxin, domoic acid (DA) and 14mer double-stranded DNA (dsDNA with three kinds of sequences) were studied by capillary zone electrophoresis (CZE). For the dsDNA with a sequence of 5'-CCCCCTATACCCGC-3', the amount of free dsDNA decreases with the increase of added DA; and the signal of DA-dsDNA complex was observed. Meanwhile, the other two dsDNAs, 5'-(C)12GC-3' and 5'-(AT)7-3', the existence of DA could not lead to the change of dsDNA signal and indicated that there is no interaction between DA and these two dsDNAs.
- DA,
- dsDNA,
- interaction,
- capillary zone electrophoresis
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