Citation: Yong YE, Xiao Lian HU, Ping LI, Ming Yu NIU, Li Feng CAO, Yu Fen ZHAO. Synthesis and Cleavage Activity of Artifical Minic Polypeptides[J]. Chinese Chemical Letters, ;2006, 17(9): 1197-1200. shu

Synthesis and Cleavage Activity of Artifical Minic Polypeptides

Yong YE ^1, ,
Xiao Lian HU ¹ ,
Ping LI ¹ ,
Ming Yu NIU ^1,2 ,
Li Feng CAO ¹ ,
Yu Fen ZHAO ^1,2

1.
Department of Chemistry, Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052;
2.
Key laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology(Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084

Received Date: 29 March 2006

Fund Project: The authors would like to thank the financial supports from NNSFC (No. 20132020 and No. 20572061).

Two artificial minic polypeptides which are synthetic analogues of natural products with DNA affinity were synthesized, and theirs cleavage activity with DNA were examined. The structures of these compounds was confirmed by ¹H NMR, MS and IR.
- DNA,
- artificial minic polypeptide,
- cleavage agents
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16. [16]
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