Citation: Xian Chao CHENG, Xin Yong LIU, Wen Fang XU. Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors[J]. Chinese Chemical Letters, ;2006, 17(10): 1317-1320. shu

Synthesis of Novel Ligustrazine Derivatives as Potential Platelet Aggregation Inhibitors

Institute of Medicinal Chemistry, School of Pharmaceutical Science, Shandong University, Jinan 250012

Received Date: 17 May 2006

Fund Project: This project was supported by Shandong Natural Science Foundation (Y2003C11), Shandong Science & Technology Bureau Foundation and Jinan Excellent Young Scientist Program.

A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, ¹H NMR and ESI-MS. The preliminary antiplatelet aggregation screening results demonstrated that the compounds 7a, 7b and 7c showed higher potency than ligustrazine.
- Synthesis,
- ligustrazine,
- derivatives,
- platelet aggregation inhibitors
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