Citation: Mu YUAN, Yu Guo ZHONG, Qi Jie PANG. Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives[J]. Chinese Chemical Letters, ;1998, 9(4): 369-371. shu

Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives

a Department of Pharmacy, Guiyang Medical College, Gujyang 550004;
b School of Pharmacy, West China University of Medical Sciences, Chengdu 610044

Received Date: 29 December 1997

Under physiological conditions, γ-aminobutyric acid poorly crosses the blood-brain barrier. It is likely that a non-toxic derivative of γ-aminobutyric acid which enters the brain easily will have useful anticonvulsant activity. 16 derivatives of γ-aminobutyric acid with an imine link to a lipophilic carrier were prepared and tested for anticonvulsant activity; six compounds show anticonvulsant activity.
- γ-aminobutyric acid,
- synthesis,
- anticonvulsant activity
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