Citation: Yu ZHAO, Yuan Ling KU, Shoei Sheng LEE. Mimetic Preparation of Analogues of Territrem B, A Potent Acetylcholinesterase Inhibitor[J]. Chinese Chemical Letters, ;2000, 11(12): 1045-1048. shu

Mimetic Preparation of Analogues of Territrem B, A Potent Acetylcholinesterase Inhibitor

1.
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
2.
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 10018

Received Date: 12 May 2000

Fund Project: This work is financially supported by National Science Council, China (Taipei) under grant NSC 87-2314-002-005. One of us (Y. Zhao) would like to express his thankfulness to NSC for offering the postdoctoral research fellowship and to National Taiwan University for affording the visiting professor employment.

A mimetic synthesis of a potent acetylcholinesterase inhibitor, Territrem B, was carried out from the naturally occurring jujubosides. The anti-AChE activity of the product, which possesses the 2-en-1-one pharmacophore and the aromatic ring, was measured. The aromatic ring moiety seemed to be less influencing when comparing with the 2-en-1-one moiety.
- Acetylcholinesterase inhibitor,
- Territrem B analogues,
- jujubosides
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