Citation: Zeng Li SONG, Jun Dong ZHANG, Li He ZHANG. SYNTHESIS OF ADENOSINE DERIVATIVES WITH CARBOXYALKYL SIDE CHAIN AT 2',3'OR 5'POSITION[J]. Chinese Chemical Letters, ;1993, 4(12): 1053-1056. shu

SYNTHESIS OF ADENOSINE DERIVATIVES WITH CARBOXYALKYL SIDE CHAIN AT 2',3'OR 5'POSITION

School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083

Received Date: 17 August 1993

Fund Project: The project was supported by the National Natural Science Foundation of China.

Some nucleoside carhoxylic acid derivatives, such as (±) ethyl ester of griseolic acid D (4) and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate) adenine (11), were synthesized. The formation of lactone of 5'-deoxy-adenosineacetic acid (AAA, 3) was investigated by using different reagents for lactonization from AAA, but all of the efforts failed, and some unexpected compounds were obtained.
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