Citation: Zong Jin HAN, Zhen Kai DING, Qi Kai ZHANG. SYNTHESIS OF A HEXACYCLOPETIDE ON SOLID SUPPORT USING BOP REAGENT[J]. Chinese Chemical Letters, ;1995, 6(8): 667-668. shu

SYNTHESIS OF A HEXACYCLOPETIDE ON SOLID SUPPORT USING BOP REAGENT

Beijing Institute of Pharmacology and Toxicology, 27 Tai Ping Road, Beijing 100850

Received Date: 16 February 1995

The linear hexapeptide(His-Gly-Asp-Ser-Gly-Asp) was synthesized on solid support.FM group was used for α carboxyl protection group at Aspl.Peptide was cyclized by BOP reagent while still attached to the solid support BOP procedure proceeded more rapidly and gave purer product than DCC/HOBt method.
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