Citation: Xu Chang HE, Zhao Ying WANG, Yun Long LI, Zhen Rong XU, Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A[J]. Chinese Chemical Letters, ;1993, 4(7): 597-600. shu

SYNTHESIS OF ANALOGUES OF HUPERZINE A

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 294 Tai-Yuan Road, Shanghai 200031

Received Date: 19 February 1993

Fund Project: This work was financially supported by a grant of the National Natural Science Foundation of China.The authors are greatly indebted to Dr.Xingzu Zhu and Mrs.Jie Feng in the Division of Pharmacology of the Institute for bio-assays.

A new Lycopodium alkaloid huperzine A (1) possesses a potent inhibitory activity of acetylcholinesterase.Six structurally simplified analogues of huperzine A, compound 6, 7, 8, 12,13 and 15, were prepared and the inhibitory activities were evaluated.
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