Citation: Ai Ming Yu, Hua Zheng YANG, Zhen Pu ZHANG. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. Chinese Chemical Letters, ;1998, 9(2): 139-142. shu

Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils

a State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071;
b State Key Laboratory of Functional Polymeric Materials for AdsorPtion and Separation, Nankai University, Tianin 300071

Received Date: 3 September 1997

Fund Project: This project is supported by the National Natural Science Foundation of China. The author thanks Dr. Ren Kangtai and Dr. Liu Huayin for their kind help.

A general method for the solid phase synthesis of hydro-uracils and thiouracils is de-scribed. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Prepa-ration of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem Ⅱ D1 protein inhibitors.
- Solid Phase Synthesis,
- Hydro-Uracils and Thiouracils,
- Photosynthesis Inhibitors
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