Citation: Wei Ge ZHANG, Ying Hua JIN, Ping QI, Kai BAO, Jin Guang LIN, Nai Li WANG, Xin Shen YAO. A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate[J]. Chinese Chemical Letters, ;2006, 17(1): 9-11. shu

A Novel Oxidative N-Demethylation of 12-Membered Macrolide with Lead Tetraacetate

1.
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016;
2.
The Research Center of Traditional Chinese Medicines and Natural Products, Research Institute of Tsinghua University, Shenzhen 518057;
3.
Department of Pharmacy, General Hospital of Beijing Military Command, Beijing 100003

Received Date: 4 April 2005

Fund Project: We gratefully acknowledged the financial support of the Liaoning Bureau of Science & Technology (20021028), Liaoning Bureau of Education (202043238) and the Shenyang Bureau of Science & Technology (02Z01060).

Reaction of 12-membered macrolide 1 with lead tetraacetate in dichloromethane afforded an unexpected, novel oxidative N-demethyl product 3.
- Oxidative N-demethylation,
- 12-membered macrolide,
- lead tetraacetate
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