Citation: He Bai SHEN, Feng WANG, Yong Tao YANG. Sequence-specific Hydrolysis of Single-stranded DNA by PNA-Cerium (Ⅳ) Adduct[J]. Chinese Chemical Letters, ;2005, 16(12): 1663-1666. shu

Sequence-specific Hydrolysis of Single-stranded DNA by PNA-Cerium (Ⅳ) Adduct

College of Life & Environment Science, Shanghai Normal University, Shanghai 200234

Received Date: 28 March 2005

Fund Project: This work was supported by the National Natural Science Foundation of China (No.20443005) and the Nanotechnology Special Projects of Shanghai (No.0352nm123).

A novel artificial site specific cleavage reagent, with peptide nucleic acid (PNA) as sequence-recognizing moiety and cerium (Ⅳ) ions as "scissors" for cleaving target DNA, was synthesized. Subsequently, it was employed in the cleavage of target 26-mer single-stranded DNA (ssDNA), which has 10-mer sequence complementary with PNA recognizer in the hybrids,under physiological conditions. Reversed-phase high-performance liquid chromatogram (RPHPLC) experiments indicated that the artificial site specific cleavage reagent could cleave the target DNA specifically.
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