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Citation:
Wei Shuo FANG, Ying LIU, Qi Cheng FANG. First Synthesis of 2α-Thiol Ether Analog of Docetaxel[J]. Chinese Chemical Letters,
;2002, 13(8): 708-710.
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A 2α-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin Ⅲ 3 via double inversion of C-2 configuration. This compound showed very weak cytotoxicity toward several tumor cell lines.
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Keywords:
- Paclitaxel,
- docetaxel,
- thiol ether
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