Citation: Yi-jie Liu, Hong-liang Jiang, Yan Li, Kang-jie Zhu. CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)[J]. Chinese Journal of Polymer Science, ;2008, 26(1): 63-71. shu

CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)

Received Date: 30 December 2006
Revised Date: 23 April 2007

The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(#61541;-caprolactone) (PLGA/PCL) blending on the morphology, shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers, the average diameter of the electrospun fibers increased from 1.35 μm to 1.95μm. The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers, resulting from the semi-crystalline nature of PCL. The degradation rate of the electrospun meshes could be modulated by PLGA/PCL composition. In addition, the electrospun meshes containing 20% PCL displayed stable dimensional morphology with degradation.
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