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Citation: Qun Xiong ZHENG, Zhao Jun XU, Xian Feng SUN, Françise GUÉRITTE, Michele CESARIO, Christopher H. K. CHENG, Han Dong SUN, Yu ZHAO. New Eudesmane and Eremophilane Derivatives from Laggera Alata[J]. Chinese Chemical Letters, ;2003, 14(4): 393-396. shu

New Eudesmane and Eremophilane Derivatives from Laggera Alata

1.
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031;
2.
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
3.
Department of Food Science, Institute of Hangzhou Commerce, Hangzhou 310035;
4.
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France;
5.
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, Hong Kong

Received Date: 15 July 2002

Fund Project: This work was financed in part by the Life Sciences Special Fund of Chinese Academy of Sciences supported by the Ministry of Finance (STZ-00-24), the Yunnan Province Foundation of Applied Basic Research (2000C0072M), Chine-France PRA BT01-02, and the opening foundation from KIB, CAS. One of the authors (Y. Zhao) would also like to express his thankfulness to the Chinese Ministry of Education as well as to Mr. Ka-Shing Lee for a "Cheung Kong Scholar Chief Professorship" in Zhejiang University.

From the aerial part of Laggera alata, a novel eremophilanoid (1) as well as two new eudesmanoids (2-3) were isolated. Their structures were elucidated by 2D-NMR technique and X-ray diffraction studies. The cytotoxic activities of these sesquiterpenes were also investigated.
- Laggera alata,
- sesquiterpene,
- eremophilanoid,
- eudesmanoid,
- X-ray diffraction,
- cytotoxicity
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