Citation: Yu Li XIE, Qin ZHU, Xing Rong QIN, Yu Yuan XIE. An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes[J]. Chinese Chemical Letters, ;2003, 14(1): 25-28. shu

An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai 200031

Received Date: 1 April 2002

A simple and efficient procedure for synthesis of 1-hydroxymcthylene-1,1-bisphosphoates from aldehydes is deseribed. This method was applied to the synthesis of nowel catcchol substituted bisphosphonatcs as the anti-ostcoporosis agents.
- Bisphosphonate,
- aldehydes,
- catechol,
- anti-osteoporosis
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