Citation: Jun Zhou, Yong-zhi Qiu, Xiao-peng Zang, Chang-wang Pan, Qiang Chen, Jian Shen, Si-cong Lin. MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J]. Chinese Journal of Polymer Science, ;2005, 23(1): 93-102. shu

MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES

Corresponding author: Si-cong Lin,
Received Date: 30 December 2003
Revised Date: 29 March 2004

N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane)(SPEU)and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR, XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro, the two materials studied, including poly-DMMCA gel, all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.
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