Citation: Qi Ming MU, Cui Hua XUE, Guo Lin ZHANG, Liang Bing WANG, Shu Hua CHEN. The Synthesis and Anion Binding of Novel Cholic Acid-based Molecular Clefts Containing Unsymmetrically Disubstituted Urea Unit[J]. Chinese Chemical Letters, ;2003, 14(12): 1211-1214. shu

The Synthesis and Anion Binding of Novel Cholic Acid-based Molecular Clefts Containing Unsymmetrically Disubstituted Urea Unit

1.
The Faculty of Chemistry, Sichuan University, Chengdu 610064;
2.
Chengdu Instituted of Biology, the Chinese Academy of Sciences, Chengdu 610041

Received Date: 11 November 2002

Fund Project: The author thanks the National Natural Science Foundation of China for the financial support (Project No.:20072026).

A novel type of chiral molecular clefts consisting of a rigid deoxycholic acid methyl ester backbone and chiral unsymmetrically disubstituted urea side chain have been designed and synthesized. All these new receptors 3a~c and the corresponding key intermediates 1a~c and 2a~c are new compounds, their structures were confirmed by ¹HNMR, IR, MS spectra and elemental analysis. These molecular clefts showed binding ability for halide anions.
- Molecular clefts,
- synthesis,
- cholic acid,
- unsymmetrically disubstituted urea
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