Citation: Gui Jie TIAN, Chuan Liang QIU, Zhe LIU, De Xin WANG. Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure[J]. Chinese Chemical Letters, ;2005, 16(1): 31-34. shu

Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure

Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 8 December 2003

Fund Project: This work was supported by the National Natural Science Foundation of China, grants No. 30271530.

Three peptide alcohols and four peptidyl N-akyl-amides were prepared by a series-connection procedure consisting of n-1 sequencial assembly on solid support followed by ammonolysis with glycinol, benzylamine or n-butylamine, and successive extractionelution through C-18 layer. All products were obtained from this procedure without further purification,in an overall yield of 75-86%.
- Ammonolysis,
- C-18 filtration,
- solid-phase synthesis.
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