Citation: Rui WANG, Xiao Yu HU, Hong JI, Xiao Jie XU, Ruo Heng ZHANG, Lu Hua LAI. THE SYNTHESIS AND 2D NMR STUDY OF DELTORPHINS[J]. Chinese Chemical Letters, ;1995, 6(4): 285-288. shu

THE SYNTHESIS AND 2D NMR STUDY OF DELTORPHINS

a National Laboratory of Applied Organic Chemistry, Department of Biology, Lanzhou University, Lanzhou, 730000.;
b Department of Chemistry, Peking University, Beijing, 100831

Received Date: 13 September 1994

Fund Project: This work was supported jointly by the National Natural Science Foundation of China and the State Education Commission of China. We thank Mr. Ma Leibin, Beijing Institute of Trace Chemistry, for his excellent work on NMR for us. We also thank the National Laboratory for Dynamic and Stable State of Molecule for partial financial support.

We synthesized Deltorphin Ⅰ,Deltorphin Ⅱ,and their L-Alanine analogs at position 2.The synthesis was carried out with SPPS and Boc strategy.The data we got from FAB MS,AAA and sequence analysis were in agreement with the caculated values.We studied the 2D NMR for Deltorphin Ⅱ and[L-Ala²]Deltorphin Ⅱ in DMSO solution.The ¹H-¹H COSY and 2D NOESY spectra were resolved by computer treatment.The conformations of C-fragment tetrapeptides of Deltorphin Ⅱ and its L-Ala analog might form a 3₁₀ α-helix.The molecular models of these two peptides were established.
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