Citation: Peng SUN, Yang Hua YI, Ling LI, Min GUI, Hai Feng TANG, Da Zhi ZHANG, Shi Long ZHANG. 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens[J]. Chinese Chemical Letters, ;2006, 17(11): 1454-1456. shu

17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuria impatiens

1.
Research Center for Marine Drugs, Pharmacy School, Second Military Medical University, Shanghai 200433;
2.
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203;
3.
Department of Pharmacy, Xijing Hospital,4th Military Medical University, Xi'an 710032;
4.
Department of Organic Chemistry, Pharmacy School, Second Military Medical University, Shanghai 200433

Received Date: 27 June 2006

A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC₅₀ values of 1.98, 4.53, 2.01, 4.69 and 2.80×10^-6 mol/L, respectively.
- Sea cucumber,
- Holothuria impatiens,
- 17-dehydroxyholothurin A,
- triterpene glycoside
1. [1]
  Zheng-Biao Zou , Tai-Zong Wu , Chun-Lan Xie , Yuan Wang , Yan Li , Gang Zhang , Rong Chao , Lian-Zhong Luo , Li-Sheng Li , Xian-Wen Yang . neo-Dicitrinols A–C: Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22. Chinese Chemical Letters, 2024, 35(12): 109723-. doi: 10.1016/j.cclet.2024.109723

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1.
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