Citation: ZHUO Renxi, LIU Zhenghua, LI Li. CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER[J]. Chinese Journal of Polymer Science, ;1989, 7(2): 179-182. shu

CHEMOTHERAPEUTIC POLYMERS ⅩⅩⅢ SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND PHOSPHONOACETIC ACID ETHYL ESTER

Received Date: 22 July 1988

Eight new polyphosphates containing both nucleic acid base and phosphonoacetic acid ethyl ester were synthesized by the polycondensation of P, P-dichloride of phosphonoacetic acid ethyl ester with 1, 3-dihydroxyalkyl-5-fluorouracil, 1,3-dihydroxyalkyl-uracil and 1,3-dihydroxyalkylthymine. These polyphosphates were tested against Ehrlich Ascites Carcinoma in mice. Polymer IIa and IIc exhibited excellent antitumor activity. IIc also showed lower toxicity.
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