Citation: Dan Dan HAN, Chun WANG, Zhi WANG, Qiu Hua WU, Xiao Huan ZANG. On-line Sweeping Sample Concentration in Micellar Electrokinetic Chromatography with Enhanced Sensitivity for the Determination of Carbamazepine in Human Serum[J]. Chinese Chemical Letters, ;2006, 17(7): 953-956. shu

On-line Sweeping Sample Concentration in Micellar Electrokinetic Chromatography with Enhanced Sensitivity for the Determination of Carbamazepine in Human Serum

1.
College of Food Science and Technology, Agricultural University of Hebei, Baoding 071001;
2.
Key Laboratory of Bioinorganic Chemistry, College of Science, Agricultural University of Hebei, Baoding 071001

Received Date: 9 January 2006

Fund Project: This project is sponsored in part by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry and partly by the Scientific Research Foundation of Department of Education, Hebei Province (2005113).

A sensitive and simple micellar electrokinetic chromatography (MEKC) method was developed for the determination of antiepileptic drug, carbamazepine (CBZ), using sweeping on-line concentration method with photodiode array detection. Under the optimal conditions, the calbration curve was linear oevr a range of 1.5-40μg·mL^-1for CBZ with a correlation clefficient of 0.998.The detection limt(S/N=3:1)of CBZ was 0.10μg·mL^-1.The sweeping-MEKC method has been successfully applied to the analysis of CBZ in human serum.
- On-line concentration,
- carbamazepine,
- MEKC,
- sweeping,
- human serum
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1.
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