Citation: Ying WANG, Hong CHEN, Zong Ming WAN, Mao Sheng CHENG, Xue Chao WANG, Guo Liang CONG, Sheng JING, Zi Ping YAN, Bo WU. Synthesis of a New Series of Bone Affinity Compounds[J]. Chinese Chemical Letters, ;2006, 17(3): 310-312. shu

Synthesis of a New Series of Bone Affinity Compounds

1.
Medical College of Chinese People's Armed Police Force, Tianjin 300162;
2.
Shenyang Pharmaceutical University, Shenyang 110016

Received Date: 8 July 2005

Fund Project: This work was supported by the National Natural Science Foundation of China (No.30371682).

A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapafive (HA)affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.
- Chrysophanol,
- 5-fluorouracil,
- bone affinity,
- antitumor
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