Citation: Wen Hui HU, Zon Ru GUO, Ai Ping BAI, Zhi Bin XU. A Convenient Synthesis of the Substituted 2,3-Diarylindole the Potent Selective COX-2 Inhibitors[J]. Chinese Chemical Letters, ;2002, 13(4): 296-298. shu

A Convenient Synthesis of the Substituted 2,3-Diarylindole the Potent Selective COX-2 Inhibitors

Department of synthetic medicinal chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 16 July 2001
Revised Date: 13 December 2001

Phenyl sulfone-containing 2,3-diarylindole derivatives were designed and identified to be selective COX-2 inhibitors.A convenient synthetic route was also developed for the synthesis of the novel inhibitors.
- Nonsteroidal anti-inflammatory drugs(NSAIDs),
- selective COX-2 inhibitors,
- substituted 2,
- 3-diarylindole,
- pharmacophore
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