Citation: Yan WANG, Hong Fang SUN, Hai Fang WANG, Yuan Fang LIU. In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition[J]. Chinese Chemical Letters, ;2001, 12(5): 449-452. shu

In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition

Department of Technical Physics, Peking University, Beijing 100871

Received Date: 17 October 2000

Fund Project: We thank the financial support of the National Natural Science Foundation of China (Grant. No. 19935020) and Research Fund for Doctoral Program of Higher Education.

he in vitro interaction of nicotine and hemoglobin (Hb) in a metabolizing system was studied by spectroscopy assays. Visible spectra showed two isobestics,and fluorescence spectra showed static quenching with increasing of nicotine dose. Meanwhile,the CD spectra intensity reduced,showing the conformation of Hb varied markedly through the interaction.All these results suggested that the interaction of nicotine or its metabolites and Hb might do harm to physicological function of Hb.
- Nicotine,
- hemoglobin,
- visible absorption,
- fluorescence,
- CD.
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