Citation: Ying ZHOU, Liang Ren ZHANG, Li He ZHANG. The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate[J]. Chinese Chemical Letters, ;1998, 9(9): 791-793. shu

The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate

National Laboratory of Natural and Biomimetic Drugs Beijing Medical University Beijing 100083

Received Date: 23 March 1998

Reaction of 5'-O-p-methoxytritylthymidine with 1,1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-0-protected thymidine to give a dinucleoside carbonate. In the synthesis of dinucleoside carbonate, allyl can be used as a good protecting group for 3'-hydroxyl of thymidine. The condition of deprotection will not affect the carbonate bridges.
- allyl,
- PdCl₂,
- deprotection,
- dinucleoside carbonate,
- synthesis
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